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Research has elucidated several other specific mechanisms through which this compound exerts its effects, particularly on cardiovascular and cancer cells

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297,298,299,301 Subsequent trials in patients with T2D and established HF showed that dapagliflozin and empagliflozin reduced the composite outcomes of worsening HF (defined as hospitalization for HF or an urgent visit for HF) or cardiovascular death by 2126%